Seek a No‑Objection Statement from your home government; if they formally waive the requirement, DOS and USCIS often follow suit even for non‑skills‑list fields.

Apply for an Interested Government Agency (IGA) waiver—show how your continued U.S. work benefits a federal agency (e.g., NIH research), overriding the skills‑list issue.

Document exceptional hardship to a U.S. citizen or LPR spouse/child; proving the move would cause them significant medical, financial, or educational harm can overcome the two‑year rule.