Possibly—he may qualify for certain relief like cancellation of removal or future parole programs, but it depends on his full history. A lawyer can evaluate his options.

If your brother has been continuously residing in the US since before January 1, 1972, he might be eligible, but given the current registry date, this seems unlikely.

 If your brother is facing deportation, he might qualify for cancellation of removal if he meets requirements, including 10 years of continuous presence and demonstrating "exceptional and extremely unusual hardship" to his US citizen children.

If your brother has a US citizen spouse or child who would suffer extreme hardship if he were denied admission, he might be eligible for a provisional waiver (Form I-601A) to overcome his unlawful presence

Yes, there may be options, especially if his U.S. citizen children are over 21 or if new programs apply—consulting an immigration attorney is crucial to assess eligibility.