You can apply for a second B-2 extension, but you must file before your current stay expires. Include strong evidence of your brother’s medical condition and your caregiving role.

A second extension is possible but not guaranteed, especially since multiple B-2 extensions raise red flags. USCIS will need detailed proof that your brother’s condition truly requires your help. Humanitarian parole is another long-shot option, but not commonly approved in situations like this.

USCIS allows more than one B-2 extension in rare and well-documented circumstances. You’ll need to submit Form I-539 again, along with updated medical records, a letter from your brother, and a personal statement explaining why your presence is critical. Mention any support you're providing, financial or physical. Timing is crucial, so don’t wait until your current stay is nearly up. While a change of status to another visa type may be harder, consulting a legal expert could open up alternatives you haven’t considered.